Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1160, Issue 1-2, Pages 194-205Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2007.05.071
Keywords
Sulfonamides; honey; API sources; precursor ion scan; selected reaction monitoring; trace analysis
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A comparison was made between electrospray, atmospheric pressure chemical and atmospheric pressure photospray ionizations to evaluate the MS/MS responses of standard sulfonamides and honey spiked samples. The sample preparation entails an acidic hydrolysis followed by a liquid/liquid extraction. Full method validation was realised by LC-APPI-MS/MS. Decision limit and detection capability were calculated for each analyte (at 50 mu g/kg) and ranged between 53.6 and 56.9 and 57.5 and 63.2 mu g/kg, respectively. Limits of detection and of quantification ranged, respectively, at 0.4-4.5 and 1.2-15.0 mu g/kg. Precursor ion scan experiments of m/z 92 were also carried out as a survey experiment, linked with an enhanced product ion scan experiment to potentially identified additional sulfonamides via a library search. (c) 2007 Elsevier B.V. All rights reserved.
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