Journal
ANALYTICA CHIMICA ACTA
Volume 787, Issue -, Pages 193-202Publisher
ELSEVIER
DOI: 10.1016/j.aca.2013.05.022
Keywords
Photonic band-gap microspheres; In vivo imaging; Gastrointestinal tract; Japanese medaka; pH-responsive
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Funding
- City University of Hong Kong [7002882]
- National Natural Science Foundation of China [51073146, 51103143, 51173175]
- University of Science & Technology of China
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Colloidal crystalline microspheres with photonic band-gap properties responsive to media pH have been developed for in vivo imaging purposes. These colloidal crystalline microspheres were constructed from monodispersed core-shell nano-size particles with poly(styrene-co-acrylic acid) (PS-co-PAA) cores and poly(acrylic acid-co-N-isopropylacrylamide) (PAA-co-PNIPAM) hydrogel shells cross-linked by N,N'-methylenebisacrylamide. A significant shift in the photonic band-gap properties of these colloidal crystalline microspheres was observed in the pH range of 4-5. This was caused by the discontinuous volume phase transition of the hydrogel coating, due to the protonation/deprotonation of its acrylic acid moieties, on the core-shell nano-sized particles within the microspheres. The in vivo imaging capability of these pH-responsive photonic microspheres was demonstrated on a test organism - Japanese medaka, Oryzia latipes - in which the morphology and change in pH along their gastrointestinal (GI) tracts were revealed under an ordinary optical microscope. This work illustrates the potential of stimuli-responsive photonic band-gap materials in tissue-/organ-level in vivo bio-imaging. (C) 2013 Elsevier B.V. All rights reserved.
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