Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 569, Issue 1-2, Pages 1-7Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2007.04.055
Keywords
diallyl disulfide; sulfane sulfur; sulfotransferases; glutathione; Ehrlich tumor
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The present in vivo studies demonstrated that diallyl disulfide (DADS), occurring in garlic, elevated hepatic sulfane sulfur level and activities of gamma-cystathionase and 3-mercaptopyruvate sulfotransferase in healthy mice but did not affect the hepatic glutathione level. DADS efficiently corrected the concentrations of glutathione and sulfane sulfur, and ameliorated gamma-cystathionase activity that had been lowered in the livers of Ehrlich ascites tumor-bearing mice. In Ehrlich ascites tumor cells, diallyl disulfide did not alter bound sulfane sulfur level, sulfotransferases activity or glutathione level. These data indicate that this compound is capable of acting efficiently and selectively only in the liver and can be used for hepatoprotection during chemotherapy. (c) 2007 Elsevier B.V All rights reserved.
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