Journal
ONCOGENE
Volume 26, Issue 37, Pages 5420-5432Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1210610
Keywords
acetylation; deacetylation; cancer; HDAC; HDAC inhibitors
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Histone deacetylases ( HDACs) regulate the expression and activity of numerous proteins involved in both cancer initiation and cancer progression. By removal of acetyl groups from histones, HDACs create a non-permissive chromatin conformation that prevents the transcription of genes that encode proteins involved in tumorigenesis. In addition to histones, HDACs bind to and deacetylate a variety of other protein targets including transcription factors and other abundant cellular proteins implicated in control of cell growth, differentiation and apoptosis. This review provides a comprehensive examination of the transcriptional and post-translational mechanisms by which HDACs alter the expression and function of cancer-associated proteins and examines the general impact of HDAC activity in cancer.
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