Journal
BIOLOGICAL PSYCHIATRY
Volume 62, Issue 4, Pages 355-358Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.08.038
Keywords
brain MAO activity; MAO A genotype
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Funding
- NCRR NIH HHS [M01 RR010710-11, M01 RR010710, M01 RR10710] Funding Source: Medline
- NIBIB NIH HHS [EB002630, R01 EB002630] Funding Source: Medline
- NIDA NIH HHS [K05 DA020001-03, K05 DA020001, K05 DA020001-04, K05 DA02001] Funding Source: Medline
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Background: A functional polymorphism in the promoter region of the monoamine oxidase A (MAO A) gene has two common alleles that are referred to as the high and low MAO A genotypes. We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects. Methods: Brain MAO A activity was measured with positron emission tomography and [C-11]clorgyline in 38 healthy adult male nonsmokers genotyped for MAO A polymorphism. Results: There was no significant difference in brain MAO A activity between the high (n = 26) and low (n = 12) MAO A genotypes. Conclusions: The lack of an association between the high and low MAO A genotype and brain MAO A activity suggests that this polymorphism by itself does not contribute to differences in brain MAO A activity in healthy adult male subjects.
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