Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 196, Issue 4, Pages 587-590Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/519741
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Funding
- NCRR NIH HHS [M01 RR000071-43, M01 RR000071, M01 RR00071] Funding Source: Medline
- NIAID NIH HHS [K23 AI050449, K23 AI50449, K23 AI050449-05] Funding Source: Medline
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A recent study found high levels of human immunodeficiency virus type 1 (HIV-1) bound to erythrocytes in HIV-1-infected patients with long-term undetectable plasma HIV-1 loads, potentially representing a novel and important reservoir of HIV-1 infection. To attempt to confirm this finding, we purified erythrocytes from 13 HIV-1-infected patients with long-term undetectable plasma viral load and depleted contaminating CD3(+) CD4(+) lymphocytes using magnetic beads. HIV-1 load of the purified erythrocyte fraction was <20 copies/mL in 11 of 13 patients and 42 and 52 copies/mL in 2 patients. Contrary to the prior report, therefore, erythrocytes do not represent a novel reservoir of HIV-1 infection in these patients.
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