Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 196, Issue 4, Pages 505-509Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/519693
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI030731, P01 AI030731, AI50132, AI071113, AI31448] Funding Source: Medline
Ask authors/readers for more resources
Clinical and virologic manifestations of genital herpes simplex virus type 2 (HSV-2) infection vary widely. We examined frequencies of single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) 2, 3, 4, and 9 in a prospective cohort of 128 HSV-2-infected persons whose viral shedding and lesion frequency was measured by daily sampling from genital secretions. Two TLR2 haplotypes (2 and 4) were associated with increased lesional (P = .008 and P = .03) and shedding (P = .02 and P = .001) rates. An SNP in haplotype 2 (- 15607A/G) was also associated with shedding (P = .01) and lesional (P = .008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available