Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 16, Pages 4428-4431Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.06.024
Keywords
antiviral; anti-tumoral; honokiol; magnolol; neolignans.
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Funding
- NIAID NIH HHS [R37 AI041980, 5P30-AI-50409, P30 AI050409-06, 5R37-AI-041980, R37 AI041980-09, P30 AI050409] Funding Source: Medline
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A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo. Published by Elsevier Ltd.
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