4.7 Article

Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres

Journal

BIOORGANIC & MEDICINAL CHEMISTRY
Volume 15, Issue 16, Pages 5615-5619

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.05.033

Keywords

aza-carbazole; natural product; bioisostere; cancer

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Aza-analogues of clausine E, mukonine and koenoline were prepared from 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde and their antiproliferative activity was evaluated against miscellaneous cancer cell lines and compared to those obtained with clausine E and mukonine. (c) 2007 Elsevier Ltd. All rights reserved.

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