Journal
STATISTICS IN MEDICINE
Volume 26, Issue 18, Pages 3398-3414Publisher
WILEY
DOI: 10.1002/sim.2730
Keywords
Alzheimer's disease; apolipoprotein E epsilon 4; direct effect; mediation effect; logit; probit
Categories
Funding
- NIA NIH HHS [R01 AG015819, P30 AG10161, R01 AG17917, R01 AG15819] Funding Source: Medline
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A mediator acts as a third variable in the causal pathway between a risk factor and an outcome. In this paper, we consider the estimation of the mediation effect when the mediator is a binary variable. We give a precise definition of the mediation effect and examine asymptotic properties of five different estimators of the mediation effect. Our theoretical developments, which are supported by a Monte Carlo study, show that the estimators that account for the binary nature of the mediator are consistent for the mediation effect defined in this paper while other estimators are inconsistent. We use these estimators to study the mediation effect of chronic cerebral infarction in the causal relationship between the apolipoprotein E epsilon 4 allele and cognitive function among 233 deceased participants from the Religious Orders Study, a longitudinal, clinical-pathologic study of aging and Alzheimer's disease. Copyright (c) 2006 John Wiley & Sons, Ltd.
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