Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 855, Issue 2, Pages 166-172Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2007.04.048
Keywords
Derris scandens; isoflavones; alpha-glucosidase inhibitors; high-performance liquid chromatography; chemobiological standardization
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The hexane and chloroform extracts of Derris scandens have displayed potent alpha-glucosidase inhibitory and moderate free radical scavenging activities. Phytochemical investigation of the active extracts led to the isolation of three new prenylated isoflavones, isoscandinone, scandenin A and scandenin B in addition to scandenone, scandinone and 4', 5', 7-trihydroxybiprenylisoflavone as the main constituents, having alpha-glucosidase enzyme inhibitory and free radical scavenging properties. A reversed-phase HPLC method is developed to quantify these active principles in the plant material, which can serve as an effective quality control method for standardization of D. scandens. (C) 2007 Elsevier B.V. All rights reserved.
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