Journal
AQUATIC TOXICOLOGY
Volume 84, Issue 1, Pages 50-61Publisher
ELSEVIER
DOI: 10.1016/j.aquatox.2007.05.013
Keywords
DNA damage; comet assay; acetylcholinesterase activity; lysosomal membrane stability; biomarker; pollution monitoring; blue mussel; Mytilus edulis
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Biomarkers of genotoxicity (DNA damage, measured as tail moment in the Comet assay), neurotoxicity (acetylcholinestcrase inhibition, AChE) and general stress (lysosomal membrane stability, LMS) were studied in native and transplanted blue mussels (Mytilus edulis) in coastal areas of western Denmark potentially affected by anthropogenic pollution originating from chemical dumping sites. The results indicate responses to pollution in all the biomarkers applied at the suspected areas, but the results were not consistent. Seasonal fluctuations in exposure situations at the study sites make interpretation of chemical pollution complex, as seen especially in the variability in results on DNA damage, and also in regard to AChE activity. These investigations further stress the importance of understanding the effects of natural factors (salinity, temperature, waterlevels, rain and storm events) in correct interpretation of the biomarker data obtained. In addition, adaptation of populations to local contamination may play a role in some of the response patterns observed. (c) 2007 Elsevier B.V. All rights reserved.
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