Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 464, Issue 2, Pages 260-268Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2007.04.007
Keywords
lipoxygenase; cyclooxygenase; lipoamino acids; endovanilloids; oxidative metabolism
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Funding
- NCI NIH HHS [R01 CA089450, R01 CA089450-09, CA89450] Funding Source: Medline
- NIDA NIH HHS [DA02014] Funding Source: Medline
- NIEHS NIH HHS [P30 ES000267, ES00267, ES07028, T32 ES007028] Funding Source: Medline
- NIGMS NIH HHS [P50 GM015431, T32 GM065086, GM65806, GM15431, P01 GM015431] Funding Source: Medline
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The lipoamino acids and endovanilloids have multiple roles in nociception, pain, and inflammation, yet their biological reactivity has not been fully characterized. Cyclooxygenases (COXs) and lipoxygenases (LOs) oxygenate polyunsaturated fatty acids to generate signaling molecules. The ability of COXs and Los to oxygenate arachidonyl-derived lipoamino acids and vanilloids was investigated. COX-1 and COX-2 were able to minimally metabolize many of these species. However, the lipoamino acids were efficiently oxygenated by 12Sand 15S-LOs. The kinetics and products of oxygenation by Los were characterized. Whereas 15S-LOs retained positional specificity of oxygenation with these novel substrates, platelet-type 12S-LO acted as a 12/15-LO. Fatty acid oxygenases may play an important role in the metabolic inactivation of lipoamino acids or vanilloids or may convert them to bioactive derivatives. (c) 2007 Elsevier Inc. All rights reserved.
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