Pharmacokinetics of Gastrodin in rat plasma and CSF after i.n. and i.v.

The pharmacokinetic behavior of Gastrodin in rat plasma and cerebrospinal fluid (CSF) after intranasal and intravenous administration (50 mg kg(-1)) was investigated. Intranasal administration of Gastrodin provided a comparable AUC in CSF compared with the intravenous administration. But Gastrodin level in plasma was very low. The ratios of AUC values of intranasal to intravenous administration were 8.85% and 105.5% in plasma and CSF, respectively. The drug targeting index (DTI) was 12.34. In conclusion, intranasal administration of Gastrodin is a promising alternative to traditional administration. Olfactory mucosa did present another pathway for transport Gastrodin to the brain. (c) 2007 Elsevier B.V. All rights reserved.