4.7 Article

Total synthesis and absolute configuration determination of (+)-bruguierol C

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 17, Pages 6621-6623

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo071035l

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The first total synthesis and absolute configuration of bruguierol C are reported. The key step involved the diastereoselective capture of an in situ generated oxocarbenium ion via an intramolecular Friedel-Crafts alkylation.

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