Journal
SCIENCE
Volume 317, Issue 5840, Pages 951-953Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1144334
Keywords
-
Categories
Funding
- NIMH NIH HHS [R01 MH53576, MH57068] Funding Source: Medline
Ask authors/readers for more resources
Little is known about the neuronal mechanisms that subserve long-term memory persistence in the brain. The components of the remodeled synaptic machinery, and how they sustain the new synaptic or cellwide configuration over time, are yet to be elucidated. In the rat cortex, long-term associative memories vanished rapidly after local application of an inhibitor of the protein kinase C isoform, protein kinase M zeta (PKM zeta). The effect was observed for at least several weeks after encoding and may be irreversible. In the neocortex, which is assumed to be the repository of multiple types of long-term memory, persistence of memory is thus dependent on ongoing activity of a protein kinase long after that memory is considered to have consolidated into a long-term stable form.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available