Journal
MOLECULAR PAIN
Volume 3, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1186/1744-8069-3-23
Keywords
-
Categories
Funding
- NINDS NIH HHS [R01 NS054069, R01 NS054069-04] Funding Source: Medline
Ask authors/readers for more resources
Detection of innocuous temperatures allows an organism to select an appropriate environmental climate, while the ability to recognize noxious temperature extremes warns of impending tissue damage. For temperatures considered cold, the menthol receptor TRPM8 is activated when temperatures drop below similar to 26 degrees C, thus making it an intriguing candidate as the molecular mediator of cold perception. However, confirmation of this hypothesis in vivo has eluded researchers until recently. Three independent research groups have reported that mice lacking this single gene are severely impaired in their ability to detect cold temperatures. Remarkably, these animals are deficient in many diverse aspects of cold signaling, including cool and noxious cold perception, injury-evoked sensitization to cold, and cooling-induced analgesia. These animals provide a great deal of insight into the molecular signaling pathways that participate in the detection of cold and painful stimuli.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available