Journal
CANCER LETTERS
Volume 253, Issue 2, Pages 236-248Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.01.026
Keywords
mTOR; p70S6K; Rapamycin; siRNA; Apoptosis; esophageal squamous cell carcinoma
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mTOR/p70S6K pathway is considered a central regulator in various malignant tumors, but its roles in esophageal squamous cell carcinoma (ESCC), which is a common cause of mortality in China, remain unknown. Here, we identify that the mTOR/p70S6K pathway is activated in ESCC; rapamycin and siRNA against mTOR rapidly inhibited expression of mTOR and the phosphorylation of its major downstream effectors, p70S6K and 4E-BP1, arrested cells in the G(0)/G(1) phase and induced apoptosis of ESCC cells. The findings may lay a foundation for making further investigations on the mTOR/p70S6K pathway as a potential target for ESCC therapy. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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