Journal
ANALYTICA CHIMICA ACTA
Volume 717, Issue -, Pages 127-133Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2011.12.037
Keywords
Colorimetric sensor; Gold nanoparticles; Fenton reaction; Ascorbic acid; Logic gates
Categories
Funding
- Natural Science Foundation of China [21075013, 20805004]
- National Science Fund for Distinguished Young Scholars [20725517]
- Fundamental Research Funds for the Central Universities [N090405004, N090105001]
Ask authors/readers for more resources
A label-free strategy based on Fenton reaction with unmodified gold nanoparticles (AuNPs) as probe is demonstrated for ascorbic acid (M) sensing. AuNPs is stable in the presence of single stranded DNA (ssDNA) which prevents salt-induced aggregation of AuNPs in solution. The hydroxyl free radicals generated by Fenton reaction lead to ssDNA cleavage into different sequence fragments which induce aggregation of AuNPs to produce a red-to-blue color change. As an efficient biological antioxidant, AA could effectively scavenge free radicals to avoid the cleavage of ssDNA, so that it prevents color change of the AuNPs solution. Thus, the color change of AuNPs in the presence and absence of AA provides a new approach for the detection of AA. The absorbance ratio at two wavelengths. A(670)/A(520), decreases linearly with AA content within 1-15 mu M, giving rise to a detection limit of 0.3 mu M and a RSD of 2.8% (10 mu M). The color display of AuNPs solution makes it feasible for the estimation of AA content by naked eye visualization. Moreover, based on Fenton reaction and unmodified gold nanoparticles, a multiple logic gate system includes two logic operations, i.e., INHIBIT and NOR, has been designed with small molecules (AA, L-cysteine, glutathione) as inputs and the colorimetric changes of AuNPs solution as outputs. (C) 2011 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available