Journal
ANALYTICA CHIMICA ACTA
Volume 694, Issue 1-2, Pages 142-150Publisher
ELSEVIER
DOI: 10.1016/j.aca.2011.02.042
Keywords
Molecular imprinting; Surface sol-gel process; TiO2 gel films; Enantiomer; Chiral discrimination
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Grants-in-Aid for Scientific Research [11J00512] Funding Source: KAKEN
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TiO2 nano-thin films with imprinted (R)- and (S)-enantiomers of propranolol, 1,1'-bi-naphthol, and 2-(4-isobutylphenyl)-propionic acid were fabricated on quartz plates by spin-coating their solutions with Ti(O-Bu-n)(4) in a toluene-ethanol mixture (1:1, v/v). After template removal, the imprinted films showed better binding for original templates than to the corresponding enantiomers. The assessment of template incorporation, template removal, and re-binding was conducted through UV-vis measurements. Significant enhancement of enantioselectivity was achieved by optimization of the film thickness and by heat-treatment of the imprinted films. After subtraction of non-specific binding, the optimized films provided chiral recognition with the enantioselectivity of almost 100% for (R)-propranolol and 95% for (S)-propranolol. (C) 2011 Elsevier B.V. All rights reserved.
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