Journal
JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE
Volume 51, Issue 4, Pages 352-355Publisher
KOREAN CHEMICAL SOC
DOI: 10.5012/jkcs.2007.51.4.352
Keywords
Bulbophyllum odoratissimum; Orchidaceae; Phenanthrene; 3,7-Dihydroxy-2,4,6-trimethoxyphenanthrene; Cytotoxicity
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Funding
- Ministry of Science and Technology, China [2005DFA30670]
- Excellent Young Teachers Program of MOE, China [2003 192]
- Yunnan Province, China [2003C0033M, 2000C0001P]
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A new phenanthrene derivative 3,7-dihydroxy-2,4,6-trimethoxyphenanthrene was isolated from the all plant of Bulbophyllum odoratissimum, and its structure was elucidated by extensive spectral studies and chemical transformation. The compound displayed cytotoxicity against the growth of human leukemia cell lines K562 and HL-60, human lung adenocarcinoma A549, human hepatoma BEL-7402 and human stomach cancer cell lines SGC-7901 with IC50 values of 14.23, 10.02, 3.42, 15.36 and 1.13 mg/ml respectively.
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