Journal
VACCINE
Volume 25, Issue 34, Pages 6313-6320Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.06.039
Keywords
BCG vaccine; cellular immunity; combined vaccines
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Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4', CD8' and remarkable -y8' T cell BCG-specific proliferation, without significant differences. Also, IL-10, IL-12, IFN-gamma and TNF-alpha concentrations in culture supernatants, measured by ELISA, were similar. The results suggested that the combined BCG and Hepatitis B vaccine was as immunogenic as BCG separated from Hepatitis B vaccine. (c) 2007 Elsevier Ltd. All rights reserved.
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