Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 182, Issue 1, Pages 140-144Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2007.05.003
Keywords
delta-opioid receptor; naltrindole 5'-isothiocyanate; nucleus accumbens; cocaine
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Funding
- NIDA NIH HHS [R01 DA012498, R01DA12498, R01 DA012498-05] Funding Source: Medline
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Whether the delta-opioid receptor (DOR) system can modulate behavioral effects of cocaine remains equivocal. We examined whether site- and subtype-selective blockade of DORs within the rat mesocorticolimbie system affects cocaine self-administration. The DOR antagonist naltrindole 5'-isothiocyanate (5'-NTII; 5 nmol) was microinjected into the nucleus accumbens (NAcc), ventral tegmental area (VTA), or arnygdala (AMYG) in rats self-administering 1.5 mg/kg cocaine under a progressive ratio (PR) schedule. Intra-NAcc 5'-NTII significantly decreased cocaine self-administration, while 5'-NTII administration into the VTA significantly increased cocaine-maintained responding. 5-NTII administration into the AMYG produced no effect. These data support a site-specific role of DORs in cocaine's behavioral effects. (c) 2007 Elsevier B. V. All rights reserved.
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