Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 569, Issue 3, Pages 197-203Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2007.05.008
Keywords
antidepressant drug; monoaminergic system; forced-swimming test; Hypericum perfoliatum; hyperfoliatin
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This study investigated, in mice, the antidepressant like effect of hyperfoliatin, a prenylated phloroglucinol derivative isolated from the aerial parts of Hypericum perfoliatum, as well as its action on monoaminergic systems. In the forced-swimming test, hyperfoliatin dose-dependently reduced immobility time. Immobility was interpreted as an expression of behavioural despair, which could be a component of depression syndrome. The effect of hyperfoliatin did not result from the stimulation of animal motor activity. Hyperfoliatin inhibited, in a concentration-dependent manner, the [H-3]-dopamine, [H-3]-serotonin and [H-3]-noradrenaline synaptosomal uptakes, but did not prevent the binding of specific ligands to the monoamine transporters. These data suggest that the antidepressant-like effect of hyperfoliatin on the forced-swimming test is probably associated to monoamine uptake inhibition, due to a mechanism of action different from that of known antidepressants. (c) 2007 Elsevier B.V. All rights reserved.
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