4.8 Article

Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 34, Pages 10304-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja072410u

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Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings offer great potential in proteomics, tissue engineering, and medical diagnostics.

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