Journal
ANALYTICA CHIMICA ACTA
Volume 675, Issue 2, Pages 106-115Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2010.07.001
Keywords
Stochastic sensing; Terrorist agents; Ion channel; Artificial nanopore; Single-channel recording; Real-world sample analysis
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Funding
- Defense Advanced Research Projects Agency [W911NF-06-01-0240, FA9550-06-C-0006]
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Nanopore stochastic sensor works by monitoring the ionic current modulations induced by the passage of analytes of interest through a single pore, which can be obtained from a biological ion channel by self-assembly or artificially fabricated in a solid-state membrane. In this minireview, we overview the use of biological nanopores and artificial nanopores for the detection of terrorist agents including explosives, organophosphorus nerve agents, nitrogen mustards, organoarsenic compounds, toxins, and viruses. We also discuss the current challenge in the development of deployable nanopore sensors for real-world applications. (C) 2010 Elsevier B.V. All rights reserved.
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