Journal
CELL BIOLOGY AND TOXICOLOGY
Volume 23, Issue 5, Pages 355-360Publisher
SPRINGER
DOI: 10.1007/s10565-007-0192-7
Keywords
glycogen synthase kinase-3; cyclosporine A; FK506; caspase; apoptosis; PC12 cells
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The purpose of this study was to examine, using glycogen synthase kinase (GSK) inhibitors, whether GSK-3 is involvedin cyclosporine A (CsA)- and FK506-induced apoptosis in PC12 cells. CsA and FK506 increased apoptotic cell death with morphological changes characterized by cell shrinkage and nuclear condensation or fragmentation. Nerve growth factor (NGF) completely blocked cell death. Caspase-3 activation was accompanied by CsA- and FK506-induced cell death and inhibited by NGF. GSK-3 inhibitors such as alsterpaullone and SB216763 prevented CsA- and FK506-induced apoptosis. These results suggest that CsA and FK506 induce caspase-dependent apoptosis and that GSK-3 activation is involved in CsA- and FK506-induced apoptosis in PC12 cells.
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