Journal
NATURE MEDICINE
Volume 13, Issue 9, Pages 1032-1034Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1624
Keywords
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Funding
- Intramural NIH HHS Funding Source: Medline
- NIAID NIH HHS [U19 AI067854-03, U19 AI067854] Funding Source: Medline
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We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1-infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.
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