Journal
ANALYTICA CHIMICA ACTA
Volume 637, Issue 1-2, Pages 92-100Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2008.08.036
Keywords
Mass spectrometry; Desorption electrospray ionisation; DESI; Hormone; Veterinary drugs; Forensic
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Hormone and veterinary drug screening and forensics can benefit from the recent developments in desorption electrospray ionisation (DESI) mass spectrometry (MS). In this work the feasibility of DESI application has been studied. Using a linear ion trap or quadrupole time-of-flight (TOF) MS instrument both full-scan and data-dependent collision-induced dissociation MS(n) spectra were acquired in seconds without sample preparation. Preliminary data are presented for the rapid screening of (pro)hormone supplement samples, an illegal steroid cocktail and forensic samples from veterinary drug investigations. The potential of this DESI approach is clearly demonstrated since compounds observed could be independently confirmed by liquid chromatography/TOFMS with accurate mass measurement, and/or proton nuclear magnetic resonance spectroscopy. Specific concerns related to false-positive and false-negative findings due to limitations in quantification and memory-effects are briefly discussed. It is envisaged that DESI will achieve a prominent role in hormone and veterinary drug analysis in the near future. (c) 2008 Elsevier B.V. All rights reserved.
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