Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 121, Issue 5, Pages 1047-1054Publisher
WILEY-LISS
DOI: 10.1002/ijc.22792
Keywords
alcoholism; alcohol dehydrogenase; saliva; acetaldehyde; bacteria; cancer
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The less-active homozygous alcohol dehydrogenase-IB (ADH1B*1/*1) and inactive heterozygous aldehyde dehydrogenase-2 (ALDH2*1/*2) increase the risk of upper aerodigestive tract cancer (UADTC) in Japanese alcoholics. We evaluated associations between ADH1B/ALDH2 genotypes and the blood and salivary ethanol/acetaldehyde levels of 80 Japanese alcoholic men in the morning when they first visited our hospital after drinking the day before. Higher levels of ethanol persisted in the blood for longer periods in ADH1B*1/*1 carriers (n = 25) than in ADH1B*2 allele carriers after adjustment for the amount and time of the preceding alcohol consumption and body weight [median (25th-75th %): 20.5 mM (15.5-52.4) vs. below detection level (
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