Journal
AUTOPHAGY
Volume 3, Issue 5, Pages 493-495Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.4594
Keywords
apopcosis; autophagy; type of cell death; chemical structure; tumor specificity
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Surveying about 1000 compounds, we found that several low molecular weight alpha, beta-unsaturated ketones induced non-apoptotic cell death characterized by the formation of autophagosomes, occasionally accompanied by mitochondrial shrinkage. The cytotoxic activity of these compounds was significantly reduced by the addition of N-acetyl-L-cysteine, suggesting their interaction with SH groups of intracellular targeted molecules (the so-called non-sterically hindered Michael acceptor). This suggests that the nature of the chemical structure as well as the type of target cells is another factor that determines the type of cell death induced by chemicals.
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