Journal
CLINICAL CHEMISTRY
Volume 53, Issue 9, Pages 1652-1657Publisher
AMER ASSOC CLINICAL CHEMISTRY
DOI: 10.1373/clinchem.2006.083923
Keywords
-
Categories
Funding
- NHLBI NIH HHS [HL39006, R01 HL073753, R01 HL085558-04, HL73753, HL77398, R01 HL077398, R01 HL039006, R01 HL085558] Funding Source: Medline
Ask authors/readers for more resources
Background: Atrial fibrillation (AF) has been associated with myocardial oxidative stress, and antioxidant agents have demonstrated antiarrhythmic benefit in humans. We compared serum markers of oxidation and associated inflammation in individuals with or without AF. Methods: Serum markers of oxidative stress and inflammation were compared in a cross-sectional, case-control design study of 40 male individuals, With or without persistent or permanent AF, who were matched for age, sex, diabetes, and smoking status, known confounding variables for the measurement of oxidative stress. We used derivatives of reactive oxidative metabolites (DROMs) and ratios of oxidized to reduced glutathione (E-h GSH) and cysteine (E-h CySH) to quantify oxidative stress. We also measured inflammatory markers, including high-sensitivity C-reactive protein, interleukins 1,6 and 6, and tumor necrosis factor alpha. Results: Univariate, conditional logistical regression analysis showed that oxidative stress but not inflammatory markers were statistically associated with AF (P < 0.05). The increase in the odds ratios for AF for Eh GSH, Eh CySH, and DROMs were 6.1 (95% CI, 1.3-28.3; P = 0.02), 13.6 (95% Cl, 2.5-74.1/i P = 0.01), and 15.9 (95% Cl, 1.7-153.9; P = 0.02), respectively. There was a stronger correlation between Eh GSH and Eh CySH (r = 0.66) than between Eh GSH and DROMs Q = 0.41). In multivariate analysis corrected for statins and other AF risk factors differing between the groups, the association of AF and oxidative stress remained significant. Conclusions: These data suggest that oxidative stress markers may have predictive value in AF management. (c) 2007 American Association for Clinical Chemistry
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available