Journal
JOURNAL OF PROTEOME RESEARCH
Volume 6, Issue 9, Pages 3691-3704Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr070222x
Keywords
IBD; experimental colitis; interleukin 10; IL-10(-/-) mice; intestinal epithelial cells; epithelial cell proteome; colitogenic bacteria; Enterococcus faecalis; galectin 3
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The interaction of nonpathogenic enteric bacteria with intestinal epithelial cells (IEC) in the absence of host-derived Interleukin 10 (IL-10) may contribute to the development of chronic inflammation. Functional proteome analysis of primary IEC from Enterococcus faecalis-monoassociated WT and IL-10(-/-) mice as well as IL-10 receptor reconstituted IEC revealed expression changes of proteins that are involved in endoplasmic reticulum stress, energy metabolism, and apoptosis, suggesting a protective role for IL-10 at the epithelial cell level.
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