Journal
PSYCHOSOMATIC MEDICINE
Volume 69, Issue 7, Pages 621-624Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PSY.0b013e31814b8de6
Keywords
5-HTTLPR; serotonin transporter promoter gene polymorphism; sleep quality; gene-environment interaction; stress
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Funding
- NCRR NIH HHS [M01RR30] Funding Source: Medline
- NHLBI NIH HHS [P01 HL036587] Funding Source: Medline
- NIA NIH HHS [R01 AG019605-05, R01 AG019605, R01AG19605] Funding Source: Medline
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Objective: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. Methods: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. Results: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. Conclusions: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.
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