Journal
EUROPEAN JOURNAL OF MEDICAL GENETICS
Volume 50, Issue 5, Pages 379-385Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejmg.2007.06.001
Keywords
chromosome 18; dysmorphology; growth retardation; isochromosome; mental retardation; ring
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We report on a baby girl from non-consanguineous Palestinian parents with intrauterine growth retardation, low birth weight, and developmental delay. She had a short stature, microcephaly, a prominent metopic suture, a glabellar haemangioma, exophthalmos, hypertelorism, upslanting palpebral fissures, horizontal nystagmus, flat nose, cleft lip and palate, a short neck, widely spaced nipples, umbilical hernia, flexion deformity of the wrist, ulnar deviation of fingers, and right club foot. Cortical atrophy, enlarged ventricles, a thin corpus callosum, thoracic hemivertebrae, and a ventricular septal defect were detected as well. High resolution chromosome analysis identified in 92% of cells an isochromosome 18 and in 8% of cells a ring 18. Molecular cytogenetic investigations confirmed that it was an i(18q) and a r(18q). The hypothesis to account for this anomaly and its corresponding phenotype are discussed. (c) 2007 Elsevier Masson SAS. All rights reserved.
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