Journal
NATURE MEDICINE
Volume 13, Issue 9, Pages 1029-1031Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1635
Keywords
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Funding
- NIA NIH HHS [P50 AG05681, R37 AG023084-02, R37 AG023084, P50 AG005681] Funding Source: Medline
- NINDS NIH HHS [R01 NS034467-07, R01 NS034467, R37 NS34467, R37 NS034467] Funding Source: Medline
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Low-density lipoprotein receptor-related protein-1 (LRP) on brain capillaries clears amyloid beta-peptide (Ab) from brain. Here, we show that soluble circulating LRP (sLRP) provides key endogenous peripheral 'sink' activity for Ab in humans. Recombinant LRP cluster IV (LRP-IV) bound Ab in plasma in mice and Alzheimer's disease-affected humans with compromised sLRP-mediated Ab binding, and reduced Ab-related pathology and dysfunction in a mouse model of Alzheimer disease, suggesting that LRP-IV can effectively replace native sLRP and clear Ab.
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