Journal
JOURNAL OF PEDIATRICS
Volume 151, Issue 3, Pages 249-254Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2007.04.009
Keywords
-
Categories
Ask authors/readers for more resources
Objective To assess the effectiveness and safety of high-dose ibuprofen when usedas part of routine therapy in patients with cystic fibrosis (CF). Study design In this multicenter, double-blinded, placebo-con trolled trial, a total of 142 patients age 6 to 18 years with mild lung disease (forced expiratory volume in I minute [FEV1] > 60 predicted) were randomized to receive either high-dose ibuprofen (70 subjects, 20 to 30 mg/kg/twice daily, adjusted to a peak serum concentration of 50 to 100 mu g/mL) or placebo (72 subjects) for a 2-year period. The primary outcome was the annualized rate of change in FEV1% predicted. Results The patients in the high-dose ibuprofen group exhibited a significant reduction in the rate of decline of forced vital capacity percent predicted (0.07 +/- 0.51 vs -1.62 +/- 0.52; P = .03), but not FEV1%. The ibuprofen group also spent fewer days in hospital after adjusting for age (1.8 vs 4.1 days per year; P = .07). A total of 11 patients (4 in the ibuprofen group and 7 in the placebo group) withdrew due to adverse events. Conclusions High-dose ibuprofen has a significant effect oil slowing the progression of lung disease in CF and generally is well tolerated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available