Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 138, Issue 6, Pages 756-760Publisher
WILEY
DOI: 10.1111/j.1365-2141.2007.06729.x
Keywords
CD47; thrombospondin; multiple myeloma; bone marrow microenvironment
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CD47 and thrombospondin 1 and 2 (TSP1 and TSP2) expression were analysed by real-time reverse transcription polymerase chain reaction in fluorescence-activated cell sorted plasma cells (PCs) from patients at consecutive stages of multiple myeloma (MM) development. 80% of MM patients, but only 39% of patients with monoclonal gammopathy of undetermined significance (MGUS) expressed CD47; median expression level increased 10-fold with progression from MGUS to MM. Elevated TSP1/TSP2 levels occurred in bone marrow cultures from MM patients compared with healthy donors. CD47 and TSP1/TSP2 may have a potential role in the pathophysiology of MM, probably in the interaction between MM PCs and the microenvironment.
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