Journal
TRENDS IN GENETICS
Volume 23, Issue 9, Pages 422-426Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2007.05.005
Keywords
-
Categories
Ask authors/readers for more resources
The tryptophan biosynthetic operon has been widely used as a model system for studying transcription regulation. In Bacillus subtilis, the trp operon is primarily regulated by a tryptophan-activated RNA-binding protein, TRAP. Here we show that in many other Gram-positive species the trp operon is regulated differently, by tRNA(Trp) sensing by the RNA-based T-box mechanism, with T-boxes arranged in tandem. Our analyses reveal an apparent relationship between trp operon organization and the specific regulatory mechanism(s) used.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available