Journal
ANALYTICA CHIMICA ACTA
Volume 609, Issue 1, Pages 44-52Publisher
ELSEVIER
DOI: 10.1016/j.aca.2007.12.032
Keywords
insulin; multiwalled carbon nanotube; multianalyte microphysiometer; Cytosensor (R); dihydropyran; sensor
Categories
Funding
- NIAID NIH HHS [U01 AI061223-04, U01 AI061223-01, U01 AI061223, U01 AI061223-03, U01 AI061223-02] Funding Source: Medline
- NIDDK NIH HHS [P60 DK20593-25, P60 DK020593, P60 DK020593-190004, P60 DK020593-25] Funding Source: Medline
- NIGMS NIH HHS [T32 GM065086] Funding Source: Medline
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We have developed a multiwalled carbon nanotube/dihydropyran (MWCNT/DHP) composite sensor for the electrochemical detection of insulin in a microfluidic device. This sensor has been employed for physiological measurements of secreted insulin from pancreatic islets in a Cytosensor (R) previously modified to be a multianalyte microphysiometer (MAMP). When compared with other established electrochemical insulin sensors, the MWCNT/DHP composite film sensor presented improved resistance to fluidic shear forces, while achieving enhanced electrode kinetics. In addition, the preparation of the composite film is straightforward and facile with a self-polymerizing monomer, DHP, used to add mechanical stability to the film. The sensor film was able to detect insulin concentrations as low as 1 mu M in the MAMP during calibration experiments. The MWCNT/DHP composite sensor has been successfully used for the direct detection of insulin secreted by islets in the microphysiometer. (C) 2008 Elsevier B.V. All rights reserved.
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