Journal
ANALYTICA CHIMICA ACTA
Volume 624, Issue 1, Pages 147-153Publisher
ELSEVIER
DOI: 10.1016/j.aca.2008.06.046
Keywords
Calophyllum inophyllum; Clusiaceae; Tamanu; inophyllums; coumarins; neoflavonoids; anti-HIV-1 agents; high pressure liquid; chromatography-UV-diode array detection; chemodiversity; multivariate analyses
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Funding
- French Polynesia Government Territory
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Various pyranocoumarins, calophyllolide, inophyllums B, C, G(1), G(2) and P, from Calophyllum inophyllum (Clusiaceae) leaves of French Polynesia (Austral, Marquesas, Society and Tuamotu archipelagos) have been determined in 136 leaf extracts using a high pressure liquid chromatography-UV-diode array detection (HPLC-UV-DAD) technique. Results show a wide range in chemical composition within trees growing on eighteen islands. The use of multivariate statistical analyses (PCA) shows geographical distribution of inophyllums and indicate those rich in HIV-1 active (+)-inophyllums. Inophyllum B and P contents (0.0-39.0 and 0.0-21.8 mg kg(-1), respectively) confirm the chemodiversity of this species within the large area of French Polynesia. The study suggests the presence of interesting chemotypes which could be used as plant source for anti-HIV-1 drugs. (C) 2008 Elsevier B.V. All rights reserved.
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