Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 114, Issue 9, Pages 1155-1159Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-007-0720-x
Keywords
1-Methyl-4-phenylpyridinium; neurotoxicity; Parkinson's disease; [F-18]2-fluoro-2-deoxy-D-glucose; positron; brain slice
Categories
Ask authors/readers for more resources
1-Methyl-4-phenylpyridinium ( MPP+) was added directly to fresh rat brain slices and the dynamic changes in the cerebral glucose metabolic rate ( CMRglc) were serially and two-dimensionally measured with [ F-18] 2-fluoro-2-deoxy-D-glucose as a tracer. MPP+ dose-dependently increased CMRglc, reflecting enhanced glycolysis compensating for the decrease in aerobic metabolism. While the CMRglc enhancement induced by MPP+ (< 10 mu M) was restricted to the striatum, MPP+ ( >= 10 mM) induced a significant CMRglc enhancement in all brain regions. MPP+ at high concentration ( 1mM) eventually initiated rapid metabolic collapse, with failure to sustain anaerobic glycolysis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available