Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 14, Issue 9, Pages 875-877Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1288
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Funding
- Medical Research Council [MC_U105663141] Funding Source: researchfish
- MRC [MC_U105663141] Funding Source: UKRI
- Medical Research Council [MC_U105663141] Funding Source: Medline
- Wellcome Trust [071102] Funding Source: Medline
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Primases synthesize the RNA primers that are necessary for replication of the parental DNA strands. Here we report that the heterodimeric archaeal/ eukaryotic primase is an iron- sulfur ( Fe- S) protein. Binding of the Fe- S cluster is mediated by an evolutionarily conserved domain at the C terminus of the large subunit. We further show that the Fe- S domain is essential to the unique ability of the eukaryotic primase to start DNA replication.
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