Journal
BIOCONJUGATE CHEMISTRY
Volume 18, Issue 5, Pages 1604-1611Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc070089z
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Lipophosphoramidates with two different permanent cations as polar heads were synthesized and evaluated for their gene transfer activity. Physicochemical measurements (particle size, zeta potentials) and gel retardation assays were also performed. In vitro biological evaluation was conducted with A542 and HeLa cell lines, and cytotoxicity determined by a chemiluminescent assay. The set of results indicates that, on the whole, dicationic lipophosphoramidates constitute an interesting alternative to their monocationic analogues.
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