Journal
ANALYST
Volume 143, Issue 20, Pages -Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8an00913a
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Funding
- Brigham Research Institute Director's Transformative Award
- NCI [R01 CA224144-01]
- Koch Institute Frontier Research Program through the Kathy and Curt Marble Cancer Research Fund
- Koch Institute Frontier Research Fund
- NIH [9P41EB015871-31]
- Samsung Advanced Institute of Technology (Seoul, South Korea)
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We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.
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