Journal
CRITICAL CARE MEDICINE
Volume 35, Issue 9, Pages S488-S495Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.CCM.0000278045.91575.30
Keywords
apoptosis; necrosis; oncosis; autophagy; burn injury; sepsis; multiple organ dysfunction syndrome; pharmacotherapy
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Funding
- NIGMS NIH HHS [R01 GM055082] Funding Source: Medline
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Dying cells are distinguished by their biochemical and morphologic traits and categorized into three subtypes: apoptosis, oncosis (necrosis), and cell death with autophagy. Each of these types of cell death plays critical roles in tissue morphogenesis during normal development and in the pathogenesis of human diseases. Given that tissue homeostasis is controlled by the intricate balance between degeneration and regeneration, it is essential to understand the mechanisms of different forms of cell death to establish and improve therapeutic interventions for prevention and rescue of these cell death-related disorders. Critical illness, including sepsis, trauma, and burn injury, is often complicated by multiple organ dysfunction syndrome and is accompanied by increased cell death in parenchymal and nonparenchymal tissues. Accumulating evidence suggests that augmented cell death plays an important role in the organ failure in critical illness. We discuss possible therapeutic approaches for prevention of cell death, particularly apoptotic cell death. (Crit Care Med 2007; 35[Suppl.]:S488-S495)
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