Journal
ANALYST
Volume 139, Issue 5, Pages 982-986Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an02162a
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Funding
- NSF [CBET-1066397]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1066397] Funding Source: National Science Foundation
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A new Sense-and-Act system was realized by the integration of a biocomputing system, performing analytical processes, with a signal responsive electrode. A drug-mimicking release process was triggered by biomolecular signals processed by different logic networks, including three concatenated AND logic gates or a 3-input OR logic gate. Biocatalytically produced NADH, controlled by various combinations of input signals, was used to activate the electrochemical system. A biocatalytic electrode associated with signal-processing biocomputing systems was electrically connected to another electrode coated with a polymer film, which was dissolved upon the formation of negative potential releasing entrapped drug-mimicking species, an enzyme-antibody conjugate, operating as a model for targeted immune-delivery and consequent prodrug activation. The system offers great versatility for future applications in controlled drug release and personalized medicine.
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