Journal
ANALYST
Volume 139, Issue 5, Pages 1134-1140Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an01933k
Keywords
-
Categories
Funding
- Australian Research Council [LP100100272]
- Flinders University
- Industry partner Inphaze Pty. Ltd, Sydney, Australia
- South Australian node of the Australian National Fabrication Facility (ANFF)
- University of Adelaide
- Australian Research Council [LP100100272] Funding Source: Australian Research Council
Ask authors/readers for more resources
Knowledge about electrochemical and electrical properties of nanopore structures and the influence of pore dimensions on these properties is important for the development of nanopore biosensing devices. The aim of this study was to explore the influence of nanopore dimensions (diameter and length) on biosensing performance using non-faradic electrochemical impedance spectroscopy (EIS). Nanoporous alumina membranes (NPAMs) prepared by self-ordered electrochemical anodization of aluminium were used as model nanopore sensing platforms. NPAMs with different pore diameters (25-65 nm) and lengths (4-18 mu m) were prepared and the internal pore surface chemistry was modified by covalently attaching streptavidin and biotin. The performance of this antibody nanopore biosensing platform was evaluated using various concentrations of biotin as a model analyte. EIS measurements of pore resistivity and conductivity were carried out for pores with different diameters and lengths. The results showed that smaller pore dimensions of 25 nm and pore lengths up to 10 mu m provide better biosensing performance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available