Journal
PEDIATRIC BLOOD & CANCER
Volume 49, Issue 3, Pages 329-332Publisher
WILEY-LISS
DOI: 10.1002/pbc.21275
Keywords
ferritin; liver iron concentration; sickle cell; thalassemia
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Funding
- NCRR NIH HHS [M01RR01271] Funding Source: Medline
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Serum ferritin (SF) and liver iron concentration (LIC), as measured by SQUID biosusceptometry, were assessed in a convenience sample of transfusion independent thalassemia patients (nTx-Thal, n = 26), regularly transfused thalassemia (Tx-Thal, n = 89), or sickle cell patients (SCID, n = 45) to investigate the severity of iron overload and the relationship between SF and LIC in nTx-Thal compared to SCD and Tx-Thal. SF correlated with LIC (Rs = 0.53, P < 0.001), but was found to be a poor predictor for LIC. SF was significantly lower (P < 0.001) in nTx-Thal patients than in other groups, despite similar LIC values. The SF-to-LIC ratio was significantly lower in nTx-Thal compared to Tx-Thal and SCD patients 6-median of 0.32, 0.87, and 1.2, respectively: P < 0.001). Due to underestimation of LIC by ferritin levels, chelation treatment may be delayed or misdirected in patients with thalassemia intermedia.
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