Journal
ANALYST
Volume 139, Issue 23, Pages 6088-6091Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4an01539h
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Funding
- State Key Basic Research Program of the PRC [2014CB744501]
- NSF of China [61271056]
- Jiangsu province natural science foundation [BK20141332]
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This article presents a simple label-free detection of nucleic acids by using Pt@mesoporousSiO(2) as a smart reporter, whose pores are first capped by single-stranded (ss) probe DNA. The detection signal is then amplified using the TMB oxidation reaction catalysed by Pt NPs while hybridizing with the complementary ss target DNA, which makes the pores of mesoporous SiO2 open through hybridization.
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